Montreal (eCanadaNow) - Yet another meta-analysis finds Glaxo’s diabetes drug is trouble - and finds the same thing about Takeda’s Actos, too. The analysis reviewed more than 78,000 patients, and estimates that one in every 50 patients taking the drugs over a 26-month period will require hospital admission due to heart failure, PharmaTimes reports.
“This means that the diabetes drugs could have caused thousands of additional cases of heart failure, creating a substantial burden on hard-pressed health services,” says Yoon Loke, a clinical pharmacologist at UEA’s School of Medicine, Health Policy and Practice. The results are being published in the August edition of the journal Diabetes Care.
The news comes on the eve of this Monday’s FDA panel meeting to decide whether Avandia should be yanked or slapped with additional warnings and restrictions. The meeting, of course, has implications for Actos, given the similarities. You can read the briefing documents, which were posted on the FDA web site yesterday, right here.
The researchers also looked at more than 200 cases of patients with heart failure related to the meds and found the problem developed even in patients taking low doses. Around 25 percent of cases occurred in people under the age of 60, even without a history of cardiovascular disease.
“These drugs are taken by more than seven million diabetic patients in the US alone, suggesting that several thousand could be harmed,” says co-author Sonal Singh of Wake Forest University.
“Most patients in the studies did not have heart failure prior to starting on treatment with these drugs,” says Loke. “There doesn’t seem to be a group of patients who are safe from these side effects.”
In the UK, Avandia and Actos are recommended for use on the country’s National Health Service, but Loke now says: “I think NICE (the UK’s cost-effectiveness body, the National Institute for Health and Clinical Excellence) should re-evaluate their decision to recommend these diabetes drugs.”
